![]() Molecular cloning of CD68, human macrophage marker related to lysosomal glycoproteins.ĭa Costa CE et al. Selectins and integrins but not platelet–endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain.īritish Journal of Pharmacology 142:772-780. Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy. Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats. ![]() Most popular CD68 antibody options at a glance, click here to view all CD68 antibodies.Įxplore CD68 antibody images by applicationīao F et al. CD68 should perhaps be regarded as a phagocytic marker and used alongside other markers to define a cell type.Ī flow cytometry protocol is available that provides detailed procedures for the treatment and staining of this intracellular marker. However CD68 expression is not unique to myeloid cells, it can also be found on hematopoietic and non-hematopoietic cells, and on carcinomas and melanomas especially in tumor stroma cells such as fibroblasts and endothelial cells. CD68 is also a member of the lysosome associated membrane protein (LAMP) family, where CD68 predominantly localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface.ĬD68 is highly expressed by monocytes and tissue macrophages, including Kupffer cells, microglia, histiocytes and osteoclasts, and to a lesser extent on dendritic cells and peripheral blood granulocytes. ![]() ![]() CD68 is a 110-kDa glycoprotein, being classified as a member of the scavenger receptor family, whose typical functions include clearance of cellular debris, promotion of phagocytosis, and the mediation, recruitment and activation of macrophages. ![]()
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